Bespoke Nanomaterials for Understanding Nano-Bio Interactions Under Flow

Replacing poly(ethylene glycol) with RAFT lipopolymers in mRNA lipid nanoparticle systems for effective gene delivery

DNBP Hassanel, EH Pilkington, Y Ju, SJ Kent, CW Pouton, NP Truong

2024-11-15

Lipid nanoparticles (LNPs) have emerged as promising carriers to efficiently transport mRNA into cells for protein translation, as..

Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

NA Fithri, Y Wu, G Cowin, F Akhter, HDN Tran, B Tse, NW van Holthe, SS Moonshi, K Peter, X Wang, NP Truong, HT Ta

2023-04-01

Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five deaths globally. Establishing a..

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Y Ju, WS Lee, EH Pilkington, HG Kelly, S Li, KJ Selva, KM Wragg, K Subbarao, THO Nguyen, LC Rowntree, LF Allen, K Bond, DA Williamson, NP Truong, M Plebanski, K Kedzierska, S Mahanty, AW Chung, F Caruso, AK Wheatley

2022-08-23

Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..

Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity

MN Vu, HG Kelly, HX Tan, JA Juno, R Esterbauer, TP Davis, NP Truong, AK Wheatley, SJ Kent

2021-05-01

Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life-thr..

Conformationally tuned antibacterial oligomers target the peptidoglycan of Gram-positive bacteria

AJ Christofferson, A Elbourne, S Cheeseman, Y Shi, M Rolland, D Cozzolino, J Chapman, CF McConville, RJ Crawford, PY Wang, NP Truong, A Anastasaki, VK Truong

2020-11-15

The recent rise of antibiotic resistance amongst Staphylococcus aureus (S. aureus) populations has made treating Staph-based infec..

Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network

MN Vu, HG Kelly, AK Wheatley, S Peng, EH Pilkington, NA Veldhuis, TP Davis, SJ Kent, NP Truong

2020-08-01

A key concept in nanomedicine is encapsulating therapeutic or diagnostic agents inside nanoparticles to prolong blood circulation ..

Antibacterial Liquid Metals: Biofilm Treatment via Magnetic Activation

Aaron Elbourne, Samuel Cheeseman, Paul Atkin, Nghia P Truong, Nitu Syed, Ali Zavabeti, Md Mohiuddin, Dorna Esrafilzadeh, Daniel Cozzolino, Chris F McConville, Michael D Dickey, Russell J Crawford, Kourosh Kalantar-Zadeh, James Chapman, Torben Daeneke, Khanh Truong Vi

2020-01-28

Antibiotic resistance has made the treatment of biofilm-related infections challenging. As such, the quest for next-generation ant..